Inhibition of Delta-induced Notch signaling using fucose analogs

Notch is a cell-surface receptor that controls cell fate decisions and is regulated by O-glycans attached to epidermal growth factor-like (EGF) repeats in its extracellular domain. Protein O-fucosyltransferase 1 (Pofut1) modifies EGF repeats with O-fucose and is essential for Notch signaling. Consti...

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Detalles Bibliográficos
Autores principales: Schneider, Michael, Kumar, Vivek, Nordstrøm, Lars Ulrik, Feng, Lei, Takeuchi, Hideyuki, Hao, Huilin, Luca, Vincent C., Garcia, K. Christopher, Stanley, Pamela, Wu, Peng, Haltiwanger, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726916/
https://www.ncbi.nlm.nih.gov/pubmed/29176671
http://dx.doi.org/10.1038/nchembio.2520

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