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Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers

BACKGROUND: In recent years, Copper-64 (T(1/2) = 12.7 h) in the chemical form of copper dichloride ([(64)Cu]CuCl(2)) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limite...

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Autores principales: Avila-Rodriguez, M.A., Rios, C., Carrasco-Hernandez, J., Manrique-Arias, J. C., Martinez-Hernandez, R., García-Pérez, F. O., Jalilian, A. R., Martinez-Rodriguez, E., Romero-Piña, M. E., Diaz-Ruiz, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727003/
https://www.ncbi.nlm.nih.gov/pubmed/29234903
http://dx.doi.org/10.1186/s13550-017-0346-4
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author Avila-Rodriguez, M.A.
Rios, C.
Carrasco-Hernandez, J.
Manrique-Arias, J. C.
Martinez-Hernandez, R.
García-Pérez, F. O.
Jalilian, A. R.
Martinez-Rodriguez, E.
Romero-Piña, M. E.
Diaz-Ruiz, A.
author_facet Avila-Rodriguez, M.A.
Rios, C.
Carrasco-Hernandez, J.
Manrique-Arias, J. C.
Martinez-Hernandez, R.
García-Pérez, F. O.
Jalilian, A. R.
Martinez-Rodriguez, E.
Romero-Piña, M. E.
Diaz-Ruiz, A.
author_sort Avila-Rodriguez, M.A.
collection PubMed
description BACKGROUND: In recent years, Copper-64 (T(1/2) = 12.7 h) in the chemical form of copper dichloride ([(64)Cu]CuCl(2)) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [(64)Cu]CuCl(2), using whole-body (WB) PET scans in healthy volunteers. Six healthy volunteers were included in this study (3 women and 3 men, mean age ± SD, 54.3 ± 8.6 years; mean weight ± SD, 77.2 ± 12.4 kg). After intravenous injection of the tracer (4.0 MBq/kg), three consecutive WB emission scans were acquired at 5, 30, and 60 min after injection. Additional scans were acquired at 5, 9, and 24 h post-injection. Low-dose CT scan without contrast was used for anatomic localization and attenuation correction. OLINDA/EXM software was used to calculate human radiation doses using the reference adult model. RESULTS: The highest uptake was in the liver, followed by lower and upper large intestine walls, and pancreas, in descending order. Urinary excretion was negligible. The critical organ was liver with a mean absorbed dose of 310 ± 67 μGy/MBq for men and 421 ± 56 μGy/MBq for women, while the mean WB effective doses were 51.2 ± 3.0 and 61.8 ± 5.2 μSv/MBq for men and women, respectively. CONCLUSIONS: To the best of our knowledge, this is the first report on biodistribution and radiation dosimetry of [(64)Cu]CuCl(2) in healthy volunteers. Measured absorbed doses and effective doses are higher than previously reported doses estimated with biodistribution data from patients with prostate cancer, a difference that could be explained not just due to altered biodistribution in cancer patients compared to healthy volunteers but most likely due to the differences in the analysis technique and assumptions in the dose calculation.
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spelling pubmed-57270032017-12-14 Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers Avila-Rodriguez, M.A. Rios, C. Carrasco-Hernandez, J. Manrique-Arias, J. C. Martinez-Hernandez, R. García-Pérez, F. O. Jalilian, A. R. Martinez-Rodriguez, E. Romero-Piña, M. E. Diaz-Ruiz, A. EJNMMI Res Original Research BACKGROUND: In recent years, Copper-64 (T(1/2) = 12.7 h) in the chemical form of copper dichloride ([(64)Cu]CuCl(2)) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [(64)Cu]CuCl(2), using whole-body (WB) PET scans in healthy volunteers. Six healthy volunteers were included in this study (3 women and 3 men, mean age ± SD, 54.3 ± 8.6 years; mean weight ± SD, 77.2 ± 12.4 kg). After intravenous injection of the tracer (4.0 MBq/kg), three consecutive WB emission scans were acquired at 5, 30, and 60 min after injection. Additional scans were acquired at 5, 9, and 24 h post-injection. Low-dose CT scan without contrast was used for anatomic localization and attenuation correction. OLINDA/EXM software was used to calculate human radiation doses using the reference adult model. RESULTS: The highest uptake was in the liver, followed by lower and upper large intestine walls, and pancreas, in descending order. Urinary excretion was negligible. The critical organ was liver with a mean absorbed dose of 310 ± 67 μGy/MBq for men and 421 ± 56 μGy/MBq for women, while the mean WB effective doses were 51.2 ± 3.0 and 61.8 ± 5.2 μSv/MBq for men and women, respectively. CONCLUSIONS: To the best of our knowledge, this is the first report on biodistribution and radiation dosimetry of [(64)Cu]CuCl(2) in healthy volunteers. Measured absorbed doses and effective doses are higher than previously reported doses estimated with biodistribution data from patients with prostate cancer, a difference that could be explained not just due to altered biodistribution in cancer patients compared to healthy volunteers but most likely due to the differences in the analysis technique and assumptions in the dose calculation. Springer Berlin Heidelberg 2017-12-12 /pmc/articles/PMC5727003/ /pubmed/29234903 http://dx.doi.org/10.1186/s13550-017-0346-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Avila-Rodriguez, M.A.
Rios, C.
Carrasco-Hernandez, J.
Manrique-Arias, J. C.
Martinez-Hernandez, R.
García-Pérez, F. O.
Jalilian, A. R.
Martinez-Rodriguez, E.
Romero-Piña, M. E.
Diaz-Ruiz, A.
Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers
title Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers
title_full Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers
title_fullStr Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers
title_full_unstemmed Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers
title_short Biodistribution and radiation dosimetry of [(64)Cu]copper dichloride: first-in-human study in healthy volunteers
title_sort biodistribution and radiation dosimetry of [(64)cu]copper dichloride: first-in-human study in healthy volunteers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727003/
https://www.ncbi.nlm.nih.gov/pubmed/29234903
http://dx.doi.org/10.1186/s13550-017-0346-4
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