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Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
BACKGROUND: Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer’s disease. Our primary goal was to ascertain whether APOE-ε4 status had...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727104/ https://www.ncbi.nlm.nih.gov/pubmed/29263671 http://dx.doi.org/10.2147/NDT.S150488 |
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author | Vila-Rodriguez, Fidel Lang, Donna J Baitz, Heather Gicas, Kristina Thorton, Allen E Ehmann, Thomas S Smith, Geoff N Barr, Alasdair M Torres, Ivan J Kopala, Lili C MacEwan, G William Müller, Daniel J Kennedy, James L Honer, William G |
author_facet | Vila-Rodriguez, Fidel Lang, Donna J Baitz, Heather Gicas, Kristina Thorton, Allen E Ehmann, Thomas S Smith, Geoff N Barr, Alasdair M Torres, Ivan J Kopala, Lili C MacEwan, G William Müller, Daniel J Kennedy, James L Honer, William G |
author_sort | Vila-Rodriguez, Fidel |
collection | PubMed |
description | BACKGROUND: Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer’s disease. Our primary goal was to ascertain whether APOE-ε4 status had a pleiotropic effect in early stages of the illness. PARTICIPANTS AND METHODS: A total of 86 first-episode psychosis (FEP) outpatients and 39 healthy volunteers were recruited. Demographic and clinical data, APOE genotyping, and a neuropsychological test battery including the California Verbal Learning Test – second edition (CVLT-II) were administered and assessed at study entry and at 1-year follow-up. Data were analyzed using mixed-model repeated measures, where the dependent variable was verbal memory indexed by California Verbal Learning Test (CVLT) Trials 1–5 total recall score. RESULTS: FEP-APOE-ε4 carriers and FEP-APOE-ε4 noncarriers had similar symptom severity, clinical outcomes, premorbid and current intelligence quotient, and exposure to antipsychotics. There was a main effect of group on CVLT 1–5 (FEP =43.30 vs control =58.25; F[1, 119.7]=42.97; P<0.001) as well as an APOE-ε4 by group by time (F[4, 116.2]=2.73, P=0.033) interaction with only FEP-APOE-ε4 carriers showing improved verbal memory at follow-up. CONCLUSION: Our study is the first to report improvement in verbal memory in persons afflicted by FEP who are APOE-ε4 carriers and replicates the prominent verbal memory deficits present in FEP. Our work provides further evidence pointing to an antagonistic pleiotropic effect of APOE-ε4 in neuropsychiatric disorders. Our results merit further research into antagonistic pleiotropic effects in schizophrenia. |
format | Online Article Text |
id | pubmed-5727104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57271042017-12-20 Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? Vila-Rodriguez, Fidel Lang, Donna J Baitz, Heather Gicas, Kristina Thorton, Allen E Ehmann, Thomas S Smith, Geoff N Barr, Alasdair M Torres, Ivan J Kopala, Lili C MacEwan, G William Müller, Daniel J Kennedy, James L Honer, William G Neuropsychiatr Dis Treat Original Research BACKGROUND: Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer’s disease. Our primary goal was to ascertain whether APOE-ε4 status had a pleiotropic effect in early stages of the illness. PARTICIPANTS AND METHODS: A total of 86 first-episode psychosis (FEP) outpatients and 39 healthy volunteers were recruited. Demographic and clinical data, APOE genotyping, and a neuropsychological test battery including the California Verbal Learning Test – second edition (CVLT-II) were administered and assessed at study entry and at 1-year follow-up. Data were analyzed using mixed-model repeated measures, where the dependent variable was verbal memory indexed by California Verbal Learning Test (CVLT) Trials 1–5 total recall score. RESULTS: FEP-APOE-ε4 carriers and FEP-APOE-ε4 noncarriers had similar symptom severity, clinical outcomes, premorbid and current intelligence quotient, and exposure to antipsychotics. There was a main effect of group on CVLT 1–5 (FEP =43.30 vs control =58.25; F[1, 119.7]=42.97; P<0.001) as well as an APOE-ε4 by group by time (F[4, 116.2]=2.73, P=0.033) interaction with only FEP-APOE-ε4 carriers showing improved verbal memory at follow-up. CONCLUSION: Our study is the first to report improvement in verbal memory in persons afflicted by FEP who are APOE-ε4 carriers and replicates the prominent verbal memory deficits present in FEP. Our work provides further evidence pointing to an antagonistic pleiotropic effect of APOE-ε4 in neuropsychiatric disorders. Our results merit further research into antagonistic pleiotropic effects in schizophrenia. Dove Medical Press 2017-12-08 /pmc/articles/PMC5727104/ /pubmed/29263671 http://dx.doi.org/10.2147/NDT.S150488 Text en © 2017 Vila-Rodriguez et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Vila-Rodriguez, Fidel Lang, Donna J Baitz, Heather Gicas, Kristina Thorton, Allen E Ehmann, Thomas S Smith, Geoff N Barr, Alasdair M Torres, Ivan J Kopala, Lili C MacEwan, G William Müller, Daniel J Kennedy, James L Honer, William G Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
title | Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
title_full | Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
title_fullStr | Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
title_full_unstemmed | Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
title_short | Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect? |
title_sort | verbal memory improvement in first-episode psychosis apoe-ε4 carriers: a pleiotropic effect? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727104/ https://www.ncbi.nlm.nih.gov/pubmed/29263671 http://dx.doi.org/10.2147/NDT.S150488 |
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