p16(Ink4a) and p21(Cip1/Waf1) promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

p16(Ink4a) and p21(Cip1/Waf1) act as tumour suppressors through induction of cellular senescence. However, senescence-independent roles of these CDK inhibitors are not well understood. Here, we report an unexpected function of p16(Ink4) and p21(Cip1/Waf1), namely, tumour promotion through chemotaxis...

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Detalles Bibliográficos
Autores principales: Okuma, Atsushi, Hanyu, Aki, Watanabe, Sugiko, Hara, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727112/
https://www.ncbi.nlm.nih.gov/pubmed/29234059
http://dx.doi.org/10.1038/s41467-017-02281-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727112/
https://www.ncbi.nlm.nih.gov/pubmed/29234059
http://dx.doi.org/10.1038/s41467-017-02281-x

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