Cargando…
Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability
RIF1 plays a key role in inhibiting DNA end resection and promoting NHEJ mediated DNA double stand break repair in G1. However, whether SUMOlyation may regulate RIF1 functions is still largely unknown. Here, we report that RIF1 is SUMOlyated in response to DNA damage. We identified PIAS4 as the prim...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727183/ https://www.ncbi.nlm.nih.gov/pubmed/29234018 http://dx.doi.org/10.1038/s41598-017-16934-w |