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Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations

Translesion DNA synthesis is an essential process that helps resume DNA replication at forks stalled near bulky adducts on the DNA. Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon (PAH) that can be metabolically activated to benzo[a]pyrene diol epoxide (BPDE), which then can react with D...

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Detalles Bibliográficos
Autores principales:	Liyanage, Pramodha S., Walker, Alice R., Brenlla, Alfonso, Cisneros, G. Andrés, Romano, Louis J., Rueda, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727293/ https://www.ncbi.nlm.nih.gov/pubmed/29234107 http://dx.doi.org/10.1038/s41598-017-17643-0

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