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A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

Superoxide dismutase 1 (SOD1) is an important metalloprotein for cellular oxidative stress defence, that is mutated in familiar variants of Amyotrophic Lateral Sclerosis (fALS). Some mutations destabilize the apo protein, leading to the formation of misfolded, toxic species. The Copper Chaperone for...

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Detalles Bibliográficos
Autores principales:	Luchinat, Enrico, Barbieri, Letizia, Banci, Lucia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727297/ https://www.ncbi.nlm.nih.gov/pubmed/29234142 http://dx.doi.org/10.1038/s41598-017-17815-y

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