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Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer
One of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727305/ https://www.ncbi.nlm.nih.gov/pubmed/29055968 http://dx.doi.org/10.1002/cam4.1210 |
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author | Campacci, Natalia de Lima, Juliana O. Carvalho, André L. Michelli, Rodrigo D. Haikel, Rafael Mauad, Edmundo Viana, Danilo V. Melendez, Matias E. Vazquez, Fabiana de L. Zanardo, Cleyton Reis, Rui M. Rossi, Benedito M. Palmero, Edenir I. |
author_facet | Campacci, Natalia de Lima, Juliana O. Carvalho, André L. Michelli, Rodrigo D. Haikel, Rafael Mauad, Edmundo Viana, Danilo V. Melendez, Matias E. Vazquez, Fabiana de L. Zanardo, Cleyton Reis, Rui M. Rossi, Benedito M. Palmero, Edenir I. |
author_sort | Campacci, Natalia |
collection | PubMed |
description | One of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary screening questionnaire (PSQ) was developed to identify families at‐risk for HCPS. The PSQ was validated using discrimination measures, and the reproducibility was estimated through kappa coefficient. Patients with at least one affirmative answer had the pedigree drawn using three alternative interview approaches: in‐person, by telephone, or letter. Validation of these approaches was done. Kappa and intraclass correlation coefficients were used to analyze data's reproducibility considering the presence of clinical criteria for HCPS. The PSQ was applied to a convenience sample of 20,000 women of which 3121 (15.6%) answered at least one affirmative question and 1938 had their pedigrees drawn. The PSQ showed sensitivity and specificity scores of 94.4% and 75%, respectively, and a kappa of 0.64. The strategies for pedigree drawing had reproducibility coefficients of 0.976 and 0.850 for the telephone and letter approaches, respectively. Pedigree analysis allowed us to identify 465 individuals (24.0%) fulfilling at least one clinical criterion for HCPS. The PSQ fulfills its function, allowing the identification of HCPS at‐risk families. The use of alternative screening methods may reduce the number of excluded at‐risk individuals/families who live in locations where oncogenetic services are not established. |
format | Online Article Text |
id | pubmed-5727305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57273052017-12-13 Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer Campacci, Natalia de Lima, Juliana O. Carvalho, André L. Michelli, Rodrigo D. Haikel, Rafael Mauad, Edmundo Viana, Danilo V. Melendez, Matias E. Vazquez, Fabiana de L. Zanardo, Cleyton Reis, Rui M. Rossi, Benedito M. Palmero, Edenir I. Cancer Med Cancer Prevention One of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary screening questionnaire (PSQ) was developed to identify families at‐risk for HCPS. The PSQ was validated using discrimination measures, and the reproducibility was estimated through kappa coefficient. Patients with at least one affirmative answer had the pedigree drawn using three alternative interview approaches: in‐person, by telephone, or letter. Validation of these approaches was done. Kappa and intraclass correlation coefficients were used to analyze data's reproducibility considering the presence of clinical criteria for HCPS. The PSQ was applied to a convenience sample of 20,000 women of which 3121 (15.6%) answered at least one affirmative question and 1938 had their pedigrees drawn. The PSQ showed sensitivity and specificity scores of 94.4% and 75%, respectively, and a kappa of 0.64. The strategies for pedigree drawing had reproducibility coefficients of 0.976 and 0.850 for the telephone and letter approaches, respectively. Pedigree analysis allowed us to identify 465 individuals (24.0%) fulfilling at least one clinical criterion for HCPS. The PSQ fulfills its function, allowing the identification of HCPS at‐risk families. The use of alternative screening methods may reduce the number of excluded at‐risk individuals/families who live in locations where oncogenetic services are not established. John Wiley and Sons Inc. 2017-10-21 /pmc/articles/PMC5727305/ /pubmed/29055968 http://dx.doi.org/10.1002/cam4.1210 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Campacci, Natalia de Lima, Juliana O. Carvalho, André L. Michelli, Rodrigo D. Haikel, Rafael Mauad, Edmundo Viana, Danilo V. Melendez, Matias E. Vazquez, Fabiana de L. Zanardo, Cleyton Reis, Rui M. Rossi, Benedito M. Palmero, Edenir I. Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title | Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_full | Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_fullStr | Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_full_unstemmed | Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_short | Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
title_sort | identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727305/ https://www.ncbi.nlm.nih.gov/pubmed/29055968 http://dx.doi.org/10.1002/cam4.1210 |
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