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Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

The two isoforms of the Bcr-Abl tyrosine kinase, p210 and p190, are associated with different leukemias and have a dramatically different signaling network, despite similar kinase activity. To provide a molecular rationale for these observations, we study the Dbl-homology (DH) and Pleckstrin-homolog...

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Detalles Bibliográficos
Autores principales:	Reckel, Sina, Gehin, Charlotte, Tardivon, Delphine, Georgeon, Sandrine, Kükenshöner, Tim, Löhr, Frank, Koide, Akiko, Buchner, Lena, Panjkovich, Alejandro, Reynaud, Aline, Pinho, Sara, Gerig, Barbara, Svergun, Dmitri, Pojer, Florence, Güntert, Peter, Dötsch, Volker, Koide, Shohei, Gavin, Anne-Claude, Hantschel, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727386/ https://www.ncbi.nlm.nih.gov/pubmed/29235475 http://dx.doi.org/10.1038/s41467-017-02313-6

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