Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Effective therapy of acute myeloid leukemia (AML) remains an unmet need. DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Through a series of data analysis and drug screening, we identified two compounds (i.e., NSC-311068 and NSC-370284) that selecti...

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Detalles Bibliográficos
Autores principales: Jiang, Xi, Hu, Chao, Ferchen, Kyle, Nie, Ji, Cui, Xiaolong, Chen, Chih-Hong, Cheng, Liting, Zuo, Zhixiang, Seibel, William, He, Chunjiang, Tang, Yixuan, Skibbe, Jennifer R., Wunderlich, Mark, Reinhold, William C., Dong, Lei, Shen, Chao, Arnovitz, Stephen, Ulrich, Bryan, Lu, Jiuwei, Weng, Hengyou, Su, Rui, Huang, Huilin, Wang, Yungui, Li, Chenying, Qin, Xi, Mulloy, James C., Zheng, Yi, Diao, Jiajie, Jin, Jie, Li, Chong, Liu, Paul P., He, Chuan, Chen, Yuan, Chen, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727390/
https://www.ncbi.nlm.nih.gov/pubmed/29235481
http://dx.doi.org/10.1038/s41467-017-02290-w

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