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Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
Several splicing-modulating compounds, including Sudemycins and Spliceostatin A, display anti-tumor properties. Combining transcriptome, bioinformatic and mutagenesis analyses, we delineate sequence determinants of the differential sensitivity of 3′ splice sites to these drugs. Sequences 5′ from the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727392/ https://www.ncbi.nlm.nih.gov/pubmed/29235465 http://dx.doi.org/10.1038/s41467-017-02007-z |