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PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to cell proliferation and growth is not known. We here show that mRNA translation stress in...

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Detalles Bibliográficos
Autores principales:	Gnanasundram, Sivakumar Vadivel, Pyndiah, Slovénie, Daskalogianni, Chrysoula, Armfield, Kate, Nylander, Karin, Wilson, Joanna B., Fåhraeus, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727396/ https://www.ncbi.nlm.nih.gov/pubmed/29235459 http://dx.doi.org/10.1038/s41467-017-02282-w

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