The mechanism and high-free-energy transition state of lac repressor–lac operator interaction

Significant, otherwise-unavailable information about mechanisms and transition states (TS) of protein folding and binding is obtained from solute effects on rate constants. Here we characterize TS for lac repressor(R)–lac operator(O) binding by analyzing effects of RO-stabilizing and RO-destabilizin...

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Detalles Bibliográficos
Autores principales: Sengupta, Rituparna, Capp, Michael W., Shkel, Irina A., Record, M. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727403/
https://www.ncbi.nlm.nih.gov/pubmed/29036376
http://dx.doi.org/10.1093/nar/gkx862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727403/
https://www.ncbi.nlm.nih.gov/pubmed/29036376
http://dx.doi.org/10.1093/nar/gkx862

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