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Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation
Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their repression are not ful...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727408/ https://www.ncbi.nlm.nih.gov/pubmed/29040764 http://dx.doi.org/10.1093/nar/gkx884 |