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Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome
Globalization has facilitated the worldwide movement and introduction of pathogens, but epizoological reconstructions of these invasions are often hindered by limited sampling and insufficient genetic resolution among isolates. Pseudogymnoascus destructans, a fungal pathogen causing the epizootic of...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727414/ https://www.ncbi.nlm.nih.gov/pubmed/29233897 http://dx.doi.org/10.1128/mBio.01941-17 |
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author | Drees, Kevin P. Lorch, Jeffrey M. Puechmaille, Sebastien J. Parise, Katy L. Wibbelt, Gudrun Hoyt, Joseph R. Sun, Keping Jargalsaikhan, Ariunbold Dalannast, Munkhnast Palmer, Jonathan M. Lindner, Daniel L. Marm Kilpatrick, A. Pearson, Talima Keim, Paul S. Blehert, David S. Foster, Jeffrey T. |
author_facet | Drees, Kevin P. Lorch, Jeffrey M. Puechmaille, Sebastien J. Parise, Katy L. Wibbelt, Gudrun Hoyt, Joseph R. Sun, Keping Jargalsaikhan, Ariunbold Dalannast, Munkhnast Palmer, Jonathan M. Lindner, Daniel L. Marm Kilpatrick, A. Pearson, Talima Keim, Paul S. Blehert, David S. Foster, Jeffrey T. |
author_sort | Drees, Kevin P. |
collection | PubMed |
description | Globalization has facilitated the worldwide movement and introduction of pathogens, but epizoological reconstructions of these invasions are often hindered by limited sampling and insufficient genetic resolution among isolates. Pseudogymnoascus destructans, a fungal pathogen causing the epizootic of white-nose syndrome in North American bats, has exhibited few genetic polymorphisms in previous studies, presenting challenges for both epizoological tracking of the spread of this fungus and for determining its evolutionary history. We used single nucleotide polymorphisms (SNPs) from whole-genome sequencing and microsatellites to construct high-resolution phylogenies of P. destructans. Shallow genetic diversity and the lack of geographic structuring among North American isolates support a recent introduction followed by expansion via clonal reproduction across the epizootic zone. Moreover, the genetic relationships of isolates within North America suggest widespread mixing and long-distance movement of the fungus. Genetic diversity among isolates of P. destructans from Europe was substantially higher than in those from North America. However, genetic distance between the North American isolates and any given European isolate was similar to the distance between the individual European isolates. In contrast, the isolates we examined from Asia were highly divergent from both European and North American isolates. Although the definitive source for introduction of the North American population has not been conclusively identified, our data support the origin of the North American invasion by P. destructans from Europe rather than Asia. |
format | Online Article Text |
id | pubmed-5727414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57274142017-12-14 Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome Drees, Kevin P. Lorch, Jeffrey M. Puechmaille, Sebastien J. Parise, Katy L. Wibbelt, Gudrun Hoyt, Joseph R. Sun, Keping Jargalsaikhan, Ariunbold Dalannast, Munkhnast Palmer, Jonathan M. Lindner, Daniel L. Marm Kilpatrick, A. Pearson, Talima Keim, Paul S. Blehert, David S. Foster, Jeffrey T. mBio Research Article Globalization has facilitated the worldwide movement and introduction of pathogens, but epizoological reconstructions of these invasions are often hindered by limited sampling and insufficient genetic resolution among isolates. Pseudogymnoascus destructans, a fungal pathogen causing the epizootic of white-nose syndrome in North American bats, has exhibited few genetic polymorphisms in previous studies, presenting challenges for both epizoological tracking of the spread of this fungus and for determining its evolutionary history. We used single nucleotide polymorphisms (SNPs) from whole-genome sequencing and microsatellites to construct high-resolution phylogenies of P. destructans. Shallow genetic diversity and the lack of geographic structuring among North American isolates support a recent introduction followed by expansion via clonal reproduction across the epizootic zone. Moreover, the genetic relationships of isolates within North America suggest widespread mixing and long-distance movement of the fungus. Genetic diversity among isolates of P. destructans from Europe was substantially higher than in those from North America. However, genetic distance between the North American isolates and any given European isolate was similar to the distance between the individual European isolates. In contrast, the isolates we examined from Asia were highly divergent from both European and North American isolates. Although the definitive source for introduction of the North American population has not been conclusively identified, our data support the origin of the North American invasion by P. destructans from Europe rather than Asia. American Society for Microbiology 2017-12-12 /pmc/articles/PMC5727414/ /pubmed/29233897 http://dx.doi.org/10.1128/mBio.01941-17 Text en Copyright © 2017 Drees et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Drees, Kevin P. Lorch, Jeffrey M. Puechmaille, Sebastien J. Parise, Katy L. Wibbelt, Gudrun Hoyt, Joseph R. Sun, Keping Jargalsaikhan, Ariunbold Dalannast, Munkhnast Palmer, Jonathan M. Lindner, Daniel L. Marm Kilpatrick, A. Pearson, Talima Keim, Paul S. Blehert, David S. Foster, Jeffrey T. Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome |
title | Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome |
title_full | Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome |
title_fullStr | Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome |
title_full_unstemmed | Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome |
title_short | Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome |
title_sort | phylogenetics of a fungal invasion: origins and widespread dispersal of white-nose syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727414/ https://www.ncbi.nlm.nih.gov/pubmed/29233897 http://dx.doi.org/10.1128/mBio.01941-17 |
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