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Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA

Imprinted genes occur in discrete clusters that are coordinately regulated by shared DNA elements called Imprinting Control Regions. H19 and Igf2 are linked imprinted genes that play critical roles in development. Loss of imprinting (LOI) at the IGF2/H19 locus on the maternal chromosome is associate...

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Detalles Bibliográficos
Autores principales:	Park, Ki-Sun, Mitra, Apratim, Rahat, Beenish, Kim, Keekwang, Pfeifer, Karl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727439/ https://www.ncbi.nlm.nih.gov/pubmed/29244185 http://dx.doi.org/10.1093/nar/gkx896

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