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Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens
Forward genetic screens using mammalian embryonic stem (ES) cells have identified genes required for numerous cellular processes. However, loss-of-function screens are more difficult to conduct in diploid cells because, in most cases, both alleles of a gene must be mutated to exhibit a phenotype. Re...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727442/ https://www.ncbi.nlm.nih.gov/pubmed/29036617 http://dx.doi.org/10.1093/nar/gkx857 |