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Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1)
Ivacaftor is a potentiator of the CFTR chloride channel and is in worldwide clinical use for the chronic treatment of cystic fibrosis in patients. There is evidence that the bioavailability of ivacaftor in the body may be influenced by the multi-drug exporter P-glycoprotein. Here we have employed pu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727471/ https://www.ncbi.nlm.nih.gov/pubmed/29235532 http://dx.doi.org/10.1038/s41598-017-17773-5 |