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Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016

We describe an outbreak of Burkholderia stabilis associated with contaminated washing gloves, a commercially available Class I medical device. Triggered by an increase in Burkholderia cepacia complex (BCC) bacteremias and the detection of BCC in unopened packages of washing gloves, an ad hoc nationa...

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Autores principales: Sommerstein, Rami, Führer, Urs, Lo Priore, Elia, Casanova, Carlo, Meinel, Dominik M, Seth-Smith, Helena MB, Kronenberg, Andreas, Koch, Daniel, Senn, Laurence, Widmer, Andreas F, Egli, Adrian, Marschall, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727593/
https://www.ncbi.nlm.nih.gov/pubmed/29233255
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.49.17-00213
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author Sommerstein, Rami
Führer, Urs
Lo Priore, Elia
Casanova, Carlo
Meinel, Dominik M
Seth-Smith, Helena MB
Kronenberg, Andreas
Koch, Daniel
Senn, Laurence
Widmer, Andreas F
Egli, Adrian
Marschall, Jonas
author_facet Sommerstein, Rami
Führer, Urs
Lo Priore, Elia
Casanova, Carlo
Meinel, Dominik M
Seth-Smith, Helena MB
Kronenberg, Andreas
Koch, Daniel
Senn, Laurence
Widmer, Andreas F
Egli, Adrian
Marschall, Jonas
author_sort Sommerstein, Rami
collection PubMed
description We describe an outbreak of Burkholderia stabilis associated with contaminated washing gloves, a commercially available Class I medical device. Triggered by an increase in Burkholderia cepacia complex (BCC) bacteremias and the detection of BCC in unopened packages of washing gloves, an ad hoc national outbreak committee comprising representatives of a public health organisation, a regulatory agency, and an expert association convened and commissioned an outbreak investigation. The investigation included retrospective case finding across Switzerland and whole genome sequencing (WGS) of isolates from cases and gloves. The investigation revealed that BCC were detected in clinical samples of 46 cases aged 17 to 91 years (33% females) from nine institutions between May 2015 and August 2016. Twenty-two isolates from case patients and 16 from washing gloves underwent WGS. All available outbreak isolates clustered within a span of < 19 differing alleles, while 13 unrelated clinical isolates differed by > 1,500 alleles. This BCC outbreak was rapidly identified, communicated, investigated and halted by an ad hoc collaboration of multiple stakeholders. WGS served as useful tool for confirming the source of the outbreak. This outbreak also highlights current regulatory limitations regarding Class I medical devices and the usefulness of a nationally coordinated outbreak response.
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spelling pubmed-57275932017-12-21 Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016 Sommerstein, Rami Führer, Urs Lo Priore, Elia Casanova, Carlo Meinel, Dominik M Seth-Smith, Helena MB Kronenberg, Andreas Koch, Daniel Senn, Laurence Widmer, Andreas F Egli, Adrian Marschall, Jonas Euro Surveill Surveillance and Outbreak Report We describe an outbreak of Burkholderia stabilis associated with contaminated washing gloves, a commercially available Class I medical device. Triggered by an increase in Burkholderia cepacia complex (BCC) bacteremias and the detection of BCC in unopened packages of washing gloves, an ad hoc national outbreak committee comprising representatives of a public health organisation, a regulatory agency, and an expert association convened and commissioned an outbreak investigation. The investigation included retrospective case finding across Switzerland and whole genome sequencing (WGS) of isolates from cases and gloves. The investigation revealed that BCC were detected in clinical samples of 46 cases aged 17 to 91 years (33% females) from nine institutions between May 2015 and August 2016. Twenty-two isolates from case patients and 16 from washing gloves underwent WGS. All available outbreak isolates clustered within a span of < 19 differing alleles, while 13 unrelated clinical isolates differed by > 1,500 alleles. This BCC outbreak was rapidly identified, communicated, investigated and halted by an ad hoc collaboration of multiple stakeholders. WGS served as useful tool for confirming the source of the outbreak. This outbreak also highlights current regulatory limitations regarding Class I medical devices and the usefulness of a nationally coordinated outbreak response. European Centre for Disease Prevention and Control (ECDC) 2017-12-07 /pmc/articles/PMC5727593/ /pubmed/29233255 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.49.17-00213 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Sommerstein, Rami
Führer, Urs
Lo Priore, Elia
Casanova, Carlo
Meinel, Dominik M
Seth-Smith, Helena MB
Kronenberg, Andreas
Koch, Daniel
Senn, Laurence
Widmer, Andreas F
Egli, Adrian
Marschall, Jonas
Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016
title Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016
title_full Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016
title_fullStr Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016
title_full_unstemmed Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016
title_short Burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, Switzerland, May 2015 to August 2016
title_sort burkholderia stabilis outbreak associated with contaminated commercially-available washing gloves, switzerland, may 2015 to august 2016
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727593/
https://www.ncbi.nlm.nih.gov/pubmed/29233255
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.49.17-00213
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