DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6

BACKGROUND: The production of reactive oxygen species (ROS) during pneumococcal meningitis (PM) leads to severe DNA damage in the neurons and is the major cause of cell death during infection. Hence, the use of antioxidants as adjuvant therapy has been investigated. Previous studies have demonstrate...

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Detalles Bibliográficos
Autores principales: Coutinho, Leonam G., de Oliveira, Ana Helena Sales, Witwer, Matthias, Leib, Stephen L., Agnez-Lima, Lucymara F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727666/
https://www.ncbi.nlm.nih.gov/pubmed/29233148
http://dx.doi.org/10.1186/s12974-017-1020-5

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