Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic...

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Detalles Bibliográficos
Autores principales: Fan, Tao, Meng, Wei-Dong, Zhang, Xingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727777/
https://www.ncbi.nlm.nih.gov/pubmed/29259671
http://dx.doi.org/10.3762/bjoc.13.258
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author Fan, Tao
Meng, Wei-Dong
Zhang, Xingang
author_facet Fan, Tao
Meng, Wei-Dong
Zhang, Xingang
author_sort Fan, Tao
collection PubMed
description An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.
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spelling pubmed-57277772017-12-19 Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides Fan, Tao Meng, Wei-Dong Zhang, Xingang Beilstein J Org Chem Full Research Paper An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction. Beilstein-Institut 2017-12-06 /pmc/articles/PMC5727777/ /pubmed/29259671 http://dx.doi.org/10.3762/bjoc.13.258 Text en Copyright © 2017, Fan et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Fan, Tao
Meng, Wei-Dong
Zhang, Xingang
Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
title Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
title_full Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
title_fullStr Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
title_full_unstemmed Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
title_short Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides
title_sort palladium-catalyzed heck-type reaction of secondary trifluoromethylated alkyl bromides
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727777/
https://www.ncbi.nlm.nih.gov/pubmed/29259671
http://dx.doi.org/10.3762/bjoc.13.258
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AT mengweidong palladiumcatalyzedhecktypereactionofsecondarytrifluoromethylatedalkylbromides
AT zhangxingang palladiumcatalyzedhecktypereactionofsecondarytrifluoromethylatedalkylbromides

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