A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final...

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Detalles Bibliográficos
Autores principales: Baumann, Marcus, Baxendale, Ian R, Deplante, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727791/
https://www.ncbi.nlm.nih.gov/pubmed/29259664
http://dx.doi.org/10.3762/bjoc.13.251
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author Baumann, Marcus
Baxendale, Ian R
Deplante, Fabien
author_facet Baumann, Marcus
Baxendale, Ian R
Deplante, Fabien
author_sort Baumann, Marcus
collection PubMed
description An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.
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spelling pubmed-57277912017-12-19 A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic Baumann, Marcus Baxendale, Ian R Deplante, Fabien Beilstein J Org Chem Full Research Paper An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams. Beilstein-Institut 2017-11-29 /pmc/articles/PMC5727791/ /pubmed/29259664 http://dx.doi.org/10.3762/bjoc.13.251 Text en Copyright © 2017, Baumann et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Baumann, Marcus
Baxendale, Ian R
Deplante, Fabien
A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
title A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
title_full A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
title_fullStr A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
title_full_unstemmed A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
title_short A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
title_sort concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727791/
https://www.ncbi.nlm.nih.gov/pubmed/29259664
http://dx.doi.org/10.3762/bjoc.13.251
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