Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks

Alternative end-joining (alt-EJ) repair of DNA double-strand breaks is associated with deletions, chromosome translocations, and genome instability. Alt-EJ frequently uses annealing of microhomologous sequences to tether broken ends. When accessible pre-existing microhomologies do not exist, we have...

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Detalles Bibliográficos
Autores principales: Khodaverdian, Varandt Y., Hanscom, Terrence, Yu, Amy Marie, Yu, Taylor L., Mak, Victoria, Brown, Alexander J., Roberts, Steven A., McVey, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728401/
https://www.ncbi.nlm.nih.gov/pubmed/29121353
http://dx.doi.org/10.1093/nar/gkx1056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728401/
https://www.ncbi.nlm.nih.gov/pubmed/29121353
http://dx.doi.org/10.1093/nar/gkx1056

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