RNase H sequence preferences influence antisense oligonucleotide efficiency

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RNase H cleaves RNA in RNA–DNA duplexes. It is present in all domains of life as well as in multiple viruses and is essential for mammalian development and for human immunodeficiency virus replication. Here, we developed a sequencing-based method to measure the cleavage of thousands of different RNA...

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Detalles Bibliográficos
Autores principales: Kiełpiński, Łukasz J., Hagedorn, Peter H., Lindow, Morten, Vinther, Jeppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728404/
https://www.ncbi.nlm.nih.gov/pubmed/29126318
http://dx.doi.org/10.1093/nar/gkx1073

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