Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction

While aging is associated with increased knowledge, it is also associated with decreased semantic integration. To investigate brain activation changes during semantic integration, a sample of forty-eight 25–75 year-old adults read sentences with high cloze (HC) and low cloze (LC) probability while f...

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Autores principales: Zhu, Zude, Yang, Fengjun, Li, Dongning, Zhou, Lianjun, Liu, Ying, Zhang, Ying, Chen, Xuezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728512/
https://www.ncbi.nlm.nih.gov/pubmed/29236772
http://dx.doi.org/10.1371/journal.pone.0189462
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author Zhu, Zude
Yang, Fengjun
Li, Dongning
Zhou, Lianjun
Liu, Ying
Zhang, Ying
Chen, Xuezhi
author_facet Zhu, Zude
Yang, Fengjun
Li, Dongning
Zhou, Lianjun
Liu, Ying
Zhang, Ying
Chen, Xuezhi
author_sort Zhu, Zude
collection PubMed
description While aging is associated with increased knowledge, it is also associated with decreased semantic integration. To investigate brain activation changes during semantic integration, a sample of forty-eight 25–75 year-old adults read sentences with high cloze (HC) and low cloze (LC) probability while functional magnetic resonance imaging was conducted. Significant age-related reduction of cloze effect (LC vs. HC) was found in several regions, especially the left middle frontal gyrus (MFG) and right inferior frontal gyrus (IFG), which play an important role in semantic integration. Moreover, when accounting for global gray matter volume reduction, the age-cloze correlation in the left MFG and right IFG was absent. The results suggest that brain structural atrophy may disrupt brain response in aging brains, which then show less brain engagement in semantic integration.
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spelling pubmed-57285122017-12-22 Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction Zhu, Zude Yang, Fengjun Li, Dongning Zhou, Lianjun Liu, Ying Zhang, Ying Chen, Xuezhi PLoS One Research Article While aging is associated with increased knowledge, it is also associated with decreased semantic integration. To investigate brain activation changes during semantic integration, a sample of forty-eight 25–75 year-old adults read sentences with high cloze (HC) and low cloze (LC) probability while functional magnetic resonance imaging was conducted. Significant age-related reduction of cloze effect (LC vs. HC) was found in several regions, especially the left middle frontal gyrus (MFG) and right inferior frontal gyrus (IFG), which play an important role in semantic integration. Moreover, when accounting for global gray matter volume reduction, the age-cloze correlation in the left MFG and right IFG was absent. The results suggest that brain structural atrophy may disrupt brain response in aging brains, which then show less brain engagement in semantic integration. Public Library of Science 2017-12-13 /pmc/articles/PMC5728512/ /pubmed/29236772 http://dx.doi.org/10.1371/journal.pone.0189462 Text en © 2017 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhu, Zude
Yang, Fengjun
Li, Dongning
Zhou, Lianjun
Liu, Ying
Zhang, Ying
Chen, Xuezhi
Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
title Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
title_full Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
title_fullStr Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
title_full_unstemmed Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
title_short Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
title_sort age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728512/
https://www.ncbi.nlm.nih.gov/pubmed/29236772
http://dx.doi.org/10.1371/journal.pone.0189462
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