Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60

Accumulation of Foxp3+ T-regulatory (Treg) cells in the tumor microenvironment is associated with tumor immune evasion and poor patient outcome in the case of many solid tumors. Current therapeutic strategies for blocking Treg functions are not Treg-specific, and display only modest and transient ef...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Wang, Liqing, Wu, Jian, Sokirniy, Ivan, Nguyen, Phuong, Bregnard, Thomas, Weinstock, Joseph, Mattern, Michael, Bezsonova, Irina, Hancock, Wayne W., Kumar, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728538/
https://www.ncbi.nlm.nih.gov/pubmed/29236775
http://dx.doi.org/10.1371/journal.pone.0189744

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