The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy

To compare BRAF V600E status of primary melanoma and brain metastases to assess for discordance by cross-sectional study, and to evaluate clinical implications on BRAF inhibitor therapy. Brain metastases are common in patients with advanced melanoma. Between 40% and 60% of melanomas demonstrate BRAF...

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Detalles Bibliográficos
Autores principales: Hannan, Enda J., O’Leary, Donal P., MacNally, Stephen P., Kay, Elaine W., Farrell, Michael A., Morris, Patrick G., Power, Colm P., Hill, Arnold D.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
5700
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728729/
https://www.ncbi.nlm.nih.gov/pubmed/29310328
http://dx.doi.org/10.1097/MD.0000000000008404

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