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Acute kidney injury due to povidone-iodine ingestion: A case report
RATIONALE: Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. There have been several case reports of acute kidney injury (AKI) in burn patients after povidone-iodine irrigation and in patients receiving the substance as a sclerotherapy agen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728773/ https://www.ncbi.nlm.nih.gov/pubmed/29310372 http://dx.doi.org/10.1097/MD.0000000000008879 |
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author | Kim, Chang Seong Kim, Sung Sun Bae, Eun Hui Ma, Seong Kwon Kim, Soo Wan |
author_facet | Kim, Chang Seong Kim, Sung Sun Bae, Eun Hui Ma, Seong Kwon Kim, Soo Wan |
author_sort | Kim, Chang Seong |
collection | PubMed |
description | RATIONALE: Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. There have been several case reports of acute kidney injury (AKI) in burn patients after povidone-iodine irrigation and in patients receiving the substance as a sclerotherapy agent for management of lymphocele after renal transplantation. However, biopsy-confirmed AKI after ingestion of povidone-iodine has not previously been described. PATIENT CONCERNS: A 47-year-old man who had apparently ingested povidone-iodine solution and presented with nausea, vomiting, and reduced urine output. Laboratory data revealed blood urea nitrogen of 124 mg/dL, serum creatinine of 6.3 mg/dL, impaired liver function, and leukocytosis. Urine iodine/creatinine ratio was markedly elevated. DIAGNOSES: Acute tubular necrosis and interstitial nephritis secondary to povidone-iodine ingestion. INTERVENTIONS: The patient was admitted to the intensive care unit and underwent continuous venovenous hemodiafiltration. Kidney biopsy showed acute tubular necrosis and interstitial nephritis. Unstained sections showed tan objects in the tubular lumina that were suspected to be povidone-iodine casts. Corticosteroid therapy (1 mg/kg/day) was started after kidney biopsy. OUTCOMES: Renal function recovered after hemodialysis and corticosteroid medication, but not completely. LESSONS: We have reported the first case of biopsy-confirmed AKI accompanied by increased urine iodine concentration following povidone-iodine ingestion. |
format | Online Article Text |
id | pubmed-5728773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-57287732017-12-20 Acute kidney injury due to povidone-iodine ingestion: A case report Kim, Chang Seong Kim, Sung Sun Bae, Eun Hui Ma, Seong Kwon Kim, Soo Wan Medicine (Baltimore) 5200 RATIONALE: Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. There have been several case reports of acute kidney injury (AKI) in burn patients after povidone-iodine irrigation and in patients receiving the substance as a sclerotherapy agent for management of lymphocele after renal transplantation. However, biopsy-confirmed AKI after ingestion of povidone-iodine has not previously been described. PATIENT CONCERNS: A 47-year-old man who had apparently ingested povidone-iodine solution and presented with nausea, vomiting, and reduced urine output. Laboratory data revealed blood urea nitrogen of 124 mg/dL, serum creatinine of 6.3 mg/dL, impaired liver function, and leukocytosis. Urine iodine/creatinine ratio was markedly elevated. DIAGNOSES: Acute tubular necrosis and interstitial nephritis secondary to povidone-iodine ingestion. INTERVENTIONS: The patient was admitted to the intensive care unit and underwent continuous venovenous hemodiafiltration. Kidney biopsy showed acute tubular necrosis and interstitial nephritis. Unstained sections showed tan objects in the tubular lumina that were suspected to be povidone-iodine casts. Corticosteroid therapy (1 mg/kg/day) was started after kidney biopsy. OUTCOMES: Renal function recovered after hemodialysis and corticosteroid medication, but not completely. LESSONS: We have reported the first case of biopsy-confirmed AKI accompanied by increased urine iodine concentration following povidone-iodine ingestion. Wolters Kluwer Health 2017-12-01 /pmc/articles/PMC5728773/ /pubmed/29310372 http://dx.doi.org/10.1097/MD.0000000000008879 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5200 Kim, Chang Seong Kim, Sung Sun Bae, Eun Hui Ma, Seong Kwon Kim, Soo Wan Acute kidney injury due to povidone-iodine ingestion: A case report |
title | Acute kidney injury due to povidone-iodine ingestion: A case report |
title_full | Acute kidney injury due to povidone-iodine ingestion: A case report |
title_fullStr | Acute kidney injury due to povidone-iodine ingestion: A case report |
title_full_unstemmed | Acute kidney injury due to povidone-iodine ingestion: A case report |
title_short | Acute kidney injury due to povidone-iodine ingestion: A case report |
title_sort | acute kidney injury due to povidone-iodine ingestion: a case report |
topic | 5200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728773/ https://www.ncbi.nlm.nih.gov/pubmed/29310372 http://dx.doi.org/10.1097/MD.0000000000008879 |
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