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Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature

RATIONALE: The radiotherapy (RT) responses of gastroenteropancreatic (GEP)-origin neuroendocrine tumors remain unclear. We report cases of favorable response after localized RT of GEP-origin neuroendocrine carcinomas (GEP-NECs). PATIENT CONCERNS: 1. An 82-year-old male presented with a lower esophag...

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Autores principales: Won, Yong Gyun, Seo, Kyung-Jin, Hyeon, Jiyeon, Shin, Ok Ran, Chang, Eundeok, Sun, Der Sheng, Won, Hae Sung, Ko, Yoon Ho, Na, Sae Jung, Lee, Su Lim, Ku, Young Mi, Lee, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728897/
https://www.ncbi.nlm.nih.gov/pubmed/29245282
http://dx.doi.org/10.1097/MD.0000000000009009
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author Won, Yong Gyun
Seo, Kyung-Jin
Hyeon, Jiyeon
Shin, Ok Ran
Chang, Eundeok
Sun, Der Sheng
Won, Hae Sung
Ko, Yoon Ho
Na, Sae Jung
Lee, Su Lim
Ku, Young Mi
Lee, Dong Soo
author_facet Won, Yong Gyun
Seo, Kyung-Jin
Hyeon, Jiyeon
Shin, Ok Ran
Chang, Eundeok
Sun, Der Sheng
Won, Hae Sung
Ko, Yoon Ho
Na, Sae Jung
Lee, Su Lim
Ku, Young Mi
Lee, Dong Soo
author_sort Won, Yong Gyun
collection PubMed
description RATIONALE: The radiotherapy (RT) responses of gastroenteropancreatic (GEP)-origin neuroendocrine tumors remain unclear. We report cases of favorable response after localized RT of GEP-origin neuroendocrine carcinomas (GEP-NECs). PATIENT CONCERNS: 1. An 82-year-old male presented with a lower esophageal mass. Positron emission tomography computed tomography (PET-CT) scan showed a lower esophageal mass and gastrohepatic lymph nodes. 2. A 52-year-old female presented with abdominal discomfort. CT scan showed a 9.8 cm-sized enhancing mass in the lesser sac abutting the stomach, pancreas and liver. 3. A 54-year-old male patient presented with anal pain and bleeding. CT scan showed a remnant mass in the perirectal area after trans-anal excision. DIAGNOSES: The diagnoses of GEP-NECs were pathologically confirmed by biopsy or excision, and immunohistochemical stainings of Ki-67, CD56, synaptophysin and chromogranin-A. INTERVENTIONS: 1. The patient was treated with definitive RT. 2. The patient was treated with RT after two cycles of etoposide-cisplatin chemotherapy. 3. The patient was treated with adjuvant RT. OUTCOMES: 1. Complete remission was achieved based on CT scan four months after RT. 2. CT scan showed partial regression of the mass with a 5 cm-diameter at six months after RT. Adjuvant chemotherapy was administered after RT. 3. The residual mass was almost completely regressed at CT scan four months after RT. LESSONS: In cases of GEP-NECs, RT can be a useful treatment modality with favorable tumor response for patients with inoperable conditions or those suffering from bulky tumor masses.
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spelling pubmed-57288972017-12-20 Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature Won, Yong Gyun Seo, Kyung-Jin Hyeon, Jiyeon Shin, Ok Ran Chang, Eundeok Sun, Der Sheng Won, Hae Sung Ko, Yoon Ho Na, Sae Jung Lee, Su Lim Ku, Young Mi Lee, Dong Soo Medicine (Baltimore) 5700 RATIONALE: The radiotherapy (RT) responses of gastroenteropancreatic (GEP)-origin neuroendocrine tumors remain unclear. We report cases of favorable response after localized RT of GEP-origin neuroendocrine carcinomas (GEP-NECs). PATIENT CONCERNS: 1. An 82-year-old male presented with a lower esophageal mass. Positron emission tomography computed tomography (PET-CT) scan showed a lower esophageal mass and gastrohepatic lymph nodes. 2. A 52-year-old female presented with abdominal discomfort. CT scan showed a 9.8 cm-sized enhancing mass in the lesser sac abutting the stomach, pancreas and liver. 3. A 54-year-old male patient presented with anal pain and bleeding. CT scan showed a remnant mass in the perirectal area after trans-anal excision. DIAGNOSES: The diagnoses of GEP-NECs were pathologically confirmed by biopsy or excision, and immunohistochemical stainings of Ki-67, CD56, synaptophysin and chromogranin-A. INTERVENTIONS: 1. The patient was treated with definitive RT. 2. The patient was treated with RT after two cycles of etoposide-cisplatin chemotherapy. 3. The patient was treated with adjuvant RT. OUTCOMES: 1. Complete remission was achieved based on CT scan four months after RT. 2. CT scan showed partial regression of the mass with a 5 cm-diameter at six months after RT. Adjuvant chemotherapy was administered after RT. 3. The residual mass was almost completely regressed at CT scan four months after RT. LESSONS: In cases of GEP-NECs, RT can be a useful treatment modality with favorable tumor response for patients with inoperable conditions or those suffering from bulky tumor masses. Wolters Kluwer Health 2017-12-08 /pmc/articles/PMC5728897/ /pubmed/29245282 http://dx.doi.org/10.1097/MD.0000000000009009 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5700
Won, Yong Gyun
Seo, Kyung-Jin
Hyeon, Jiyeon
Shin, Ok Ran
Chang, Eundeok
Sun, Der Sheng
Won, Hae Sung
Ko, Yoon Ho
Na, Sae Jung
Lee, Su Lim
Ku, Young Mi
Lee, Dong Soo
Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature
title Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature
title_full Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature
title_fullStr Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature
title_full_unstemmed Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature
title_short Gastroenteropancreatic—origin neuroendocrine carcinomas: Three case reports with favorable responses following localized radiotherapy and a review of literature
title_sort gastroenteropancreatic—origin neuroendocrine carcinomas: three case reports with favorable responses following localized radiotherapy and a review of literature
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728897/
https://www.ncbi.nlm.nih.gov/pubmed/29245282
http://dx.doi.org/10.1097/MD.0000000000009009
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