Cargando…
Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease
BACKGROUND: Coronary atherosclerotic heart disease (CAD) is mainly caused by atherosclerosis, an inflammatory disease characterized by plaque formation in arteries. Reactive oxygen species caused structural damage and dysfunction of arterial endothelial cells. Thioredoxin-interacting protein (TXNIP)...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728958/ https://www.ncbi.nlm.nih.gov/pubmed/29245343 http://dx.doi.org/10.1097/MD.0000000000009108 |
_version_ | 1783286118641303552 |
---|---|
author | Zhang, Yujing Huang, Jian Yang, Xinglin Sun, Xiaofei Xu, Qincheng Wang, Baokui Zhong, Peng Wei, Zixiu |
author_facet | Zhang, Yujing Huang, Jian Yang, Xinglin Sun, Xiaofei Xu, Qincheng Wang, Baokui Zhong, Peng Wei, Zixiu |
author_sort | Zhang, Yujing |
collection | PubMed |
description | BACKGROUND: Coronary atherosclerotic heart disease (CAD) is mainly caused by atherosclerosis, an inflammatory disease characterized by plaque formation in arteries. Reactive oxygen species caused structural damage and dysfunction of arterial endothelial cells. Thioredoxin-interacting protein (TXNIP) is the endogenous inhibitor and regulator of thioredoxin, a major cellular antioxidant and antiapoptotic system. In order to explore the role of TXNIP in the occurrence and development of CAD, we detected the TXNIP expression and discussed its molecular mechanisms in CAD. METHODS: The mRNA levels of TXNIP gene in peripheral leucocytes were detected in CAD and healthy controls (CTR) by quantitative real-time polymerase chain reaction. And TXNIP proteins were detected by western blotting. RESULTS: TXNIP gene expression levels in patients with unstable angina pectoris (UAP, n = 96) were significantly increased compared with those of CTR (n = 192, P < .05). However, the situation is different in acute myocardial infarction (n = 96, P > .05). Logistic regression analysis showed that TXNIP levels were significantly positive correlated with UAP (OR = 1.728, P < .05). CONCLUSIONS: TXNIP gene expression in the peripheral leucocytes was increased in patients with UAP, indicating that TXNIP in circulating leucocytes may be involved in the pathogenesis of UAP. |
format | Online Article Text |
id | pubmed-5728958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-57289582017-12-20 Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease Zhang, Yujing Huang, Jian Yang, Xinglin Sun, Xiaofei Xu, Qincheng Wang, Baokui Zhong, Peng Wei, Zixiu Medicine (Baltimore) 3400 BACKGROUND: Coronary atherosclerotic heart disease (CAD) is mainly caused by atherosclerosis, an inflammatory disease characterized by plaque formation in arteries. Reactive oxygen species caused structural damage and dysfunction of arterial endothelial cells. Thioredoxin-interacting protein (TXNIP) is the endogenous inhibitor and regulator of thioredoxin, a major cellular antioxidant and antiapoptotic system. In order to explore the role of TXNIP in the occurrence and development of CAD, we detected the TXNIP expression and discussed its molecular mechanisms in CAD. METHODS: The mRNA levels of TXNIP gene in peripheral leucocytes were detected in CAD and healthy controls (CTR) by quantitative real-time polymerase chain reaction. And TXNIP proteins were detected by western blotting. RESULTS: TXNIP gene expression levels in patients with unstable angina pectoris (UAP, n = 96) were significantly increased compared with those of CTR (n = 192, P < .05). However, the situation is different in acute myocardial infarction (n = 96, P > .05). Logistic regression analysis showed that TXNIP levels were significantly positive correlated with UAP (OR = 1.728, P < .05). CONCLUSIONS: TXNIP gene expression in the peripheral leucocytes was increased in patients with UAP, indicating that TXNIP in circulating leucocytes may be involved in the pathogenesis of UAP. Wolters Kluwer Health 2017-12-08 /pmc/articles/PMC5728958/ /pubmed/29245343 http://dx.doi.org/10.1097/MD.0000000000009108 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0 |
spellingShingle | 3400 Zhang, Yujing Huang, Jian Yang, Xinglin Sun, Xiaofei Xu, Qincheng Wang, Baokui Zhong, Peng Wei, Zixiu Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
title | Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
title_full | Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
title_fullStr | Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
title_full_unstemmed | Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
title_short | Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
title_sort | altered expression of txnip in the peripheral leukocytes of patients with coronary atherosclerotic heart disease |
topic | 3400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728958/ https://www.ncbi.nlm.nih.gov/pubmed/29245343 http://dx.doi.org/10.1097/MD.0000000000009108 |
work_keys_str_mv | AT zhangyujing alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT huangjian alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT yangxinglin alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT sunxiaofei alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT xuqincheng alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT wangbaokui alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT zhongpeng alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease AT weizixiu alteredexpressionoftxnipintheperipheralleukocytesofpatientswithcoronaryatheroscleroticheartdisease |