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Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report
RATIONALE: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all. Polynucleotides (PN) are recently noted as a valid substitute for HA. PATIENT CONCERNS...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728967/ https://www.ncbi.nlm.nih.gov/pubmed/29245352 http://dx.doi.org/10.1097/MD.0000000000009127 |
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author | Mun, Jong-Uk Cho, Hyung Rae Choi, Young Soon Kim, Young Uk |
author_facet | Mun, Jong-Uk Cho, Hyung Rae Choi, Young Soon Kim, Young Uk |
author_sort | Mun, Jong-Uk |
collection | PubMed |
description | RATIONALE: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all. Polynucleotides (PN) are recently noted as a valid substitute for HA. PATIENT CONCERNS: A 61-year-old female was admitted to the pain center with symptoms of pain over the knee and warmth feeling with stiffness in the left knee. The patient reported chronic severe pain in the left knee area despite 6 times IAI of HA. She had past medical history of breast cancer and thyroid cancer. DIAGNOSES: She was diagnosed as having KOA. INTERVENTIONS: Ultrasound-guided IAI of PN was carried out 3 times in 3 weeks. OUTCOMES: She was followed-up for more than 5 months with good improvement in intractable knee pain without any adverse event. LESSONS: IAI of PN is an efficient therapeutic option for KOA treatment if HA injection is unsuccessful. |
format | Online Article Text |
id | pubmed-5728967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-57289672017-12-20 Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report Mun, Jong-Uk Cho, Hyung Rae Choi, Young Soon Kim, Young Uk Medicine (Baltimore) 3300 RATIONALE: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all. Polynucleotides (PN) are recently noted as a valid substitute for HA. PATIENT CONCERNS: A 61-year-old female was admitted to the pain center with symptoms of pain over the knee and warmth feeling with stiffness in the left knee. The patient reported chronic severe pain in the left knee area despite 6 times IAI of HA. She had past medical history of breast cancer and thyroid cancer. DIAGNOSES: She was diagnosed as having KOA. INTERVENTIONS: Ultrasound-guided IAI of PN was carried out 3 times in 3 weeks. OUTCOMES: She was followed-up for more than 5 months with good improvement in intractable knee pain without any adverse event. LESSONS: IAI of PN is an efficient therapeutic option for KOA treatment if HA injection is unsuccessful. Wolters Kluwer Health 2017-12-08 /pmc/articles/PMC5728967/ /pubmed/29245352 http://dx.doi.org/10.1097/MD.0000000000009127 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 3300 Mun, Jong-Uk Cho, Hyung Rae Choi, Young Soon Kim, Young Uk Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report |
title | Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report |
title_full | Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report |
title_fullStr | Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report |
title_full_unstemmed | Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report |
title_short | Effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: A case report |
title_sort | effect of multiple intra-articular injections of polynucleotides on treatment of intractable knee osteoarthritis: a case report |
topic | 3300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728967/ https://www.ncbi.nlm.nih.gov/pubmed/29245352 http://dx.doi.org/10.1097/MD.0000000000009127 |
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