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Paroxetine‐induced QTc prolongation
There have been only two previous reports of paroxetine‐induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43‐year‐old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729323/ https://www.ncbi.nlm.nih.gov/pubmed/29264083 http://dx.doi.org/10.1002/jgf2.137 |
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author | Otsuka, Yuji |
author_facet | Otsuka, Yuji |
author_sort | Otsuka, Yuji |
collection | PubMed |
description | There have been only two previous reports of paroxetine‐induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43‐year‐old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether‐a‐go‐go‐related gene (HERG) channels. Genetic polymorphisms of channels related to cardiac function are involved in drug‐induced QTc prolongation. Moreover, autonomic nervous system instability due to unstable psychotic symptoms may also affect QTc. These factors are related to this rare event induced by paroxetine. |
format | Online Article Text |
id | pubmed-5729323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57293232017-12-20 Paroxetine‐induced QTc prolongation Otsuka, Yuji J Gen Fam Med Case Reports There have been only two previous reports of paroxetine‐induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43‐year‐old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether‐a‐go‐go‐related gene (HERG) channels. Genetic polymorphisms of channels related to cardiac function are involved in drug‐induced QTc prolongation. Moreover, autonomic nervous system instability due to unstable psychotic symptoms may also affect QTc. These factors are related to this rare event induced by paroxetine. John Wiley and Sons Inc. 2017-09-25 /pmc/articles/PMC5729323/ /pubmed/29264083 http://dx.doi.org/10.1002/jgf2.137 Text en © 2017 The Authors. Journal of General and Family Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Primary Care Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Otsuka, Yuji Paroxetine‐induced QTc prolongation |
title | Paroxetine‐induced QTc prolongation |
title_full | Paroxetine‐induced QTc prolongation |
title_fullStr | Paroxetine‐induced QTc prolongation |
title_full_unstemmed | Paroxetine‐induced QTc prolongation |
title_short | Paroxetine‐induced QTc prolongation |
title_sort | paroxetine‐induced qtc prolongation |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729323/ https://www.ncbi.nlm.nih.gov/pubmed/29264083 http://dx.doi.org/10.1002/jgf2.137 |
work_keys_str_mv | AT otsukayuji paroxetineinducedqtcprolongation |