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Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia
Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack. Human KIR haplotypes comprise genes encoding mainly inhibitory receptors (KIR A) or activating and inh...
Autores principales: | Bernson, E, Hallner, A, Sander, F E, Wilsson, O, Werlenius, O, Rydström, A, Kiffin, R, Brune, M, Foà, R, Aurelius, J, Martner, A, Hellstrand, K, Thorén, F B |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729331/ https://www.ncbi.nlm.nih.gov/pubmed/28529313 http://dx.doi.org/10.1038/leu.2017.151 |
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