JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias

While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid (GC) resistance is more common than resistance to other chemotherapies at re...

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Detalles Bibliográficos
Autores principales: Delgado-Martin, C, Meyer, L K, Huang, B J, Shimano, K A, Zinter, M S, Nguyen, J V, Smith, G A, Taunton, J, Winter, S S, Roderick, J R, Kelliher, M A, Horton, T M, Wood, B L, Teachey, D T, Hermiston, M L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729333/
https://www.ncbi.nlm.nih.gov/pubmed/28484265
http://dx.doi.org/10.1038/leu.2017.136

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