Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches

In excess of 90% of patients with polycythaemia vera (PV) express a mutated form of Janus kinase 2 (JAK2), JAK2V617F. Such aberrant proteins offer great potential for the treatment of these diseases; however, inhibitors to JAK2 have had limited success in the clinic in terms of curing the disease. T...

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Detalles Bibliográficos
Autores principales: Pearson, S, Williamson, A J K, Blance, R, Somervaille, T C P, Taylor, S, Azadbakht, N, Whetton, A D, Pierce, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729335/
https://www.ncbi.nlm.nih.gov/pubmed/28533538
http://dx.doi.org/10.1038/leu.2017.143

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