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AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
BACKGROUND: N-arachidonoylphenolamine (AM404), a paracetamol metabolite, is a potent agonist of the transient receptor potential vanilloid type 1 (TRPV1) and low-affinity ligand of the cannabinoid receptor type 1 (CB1). There is evidence that AM404 exerts its pharmacological effects in immune cells....
Autores principales: | Saliba, Soraya Wilke, Marcotegui, Ariel R., Fortwängler, Ellen, Ditrich, Johannes, Perazzo, Juan Carlos, Muñoz, Eduardo, de Oliveira, Antônio Carlos Pinheiro, Fiebich, Bernd L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729401/ https://www.ncbi.nlm.nih.gov/pubmed/29237478 http://dx.doi.org/10.1186/s12974-017-1014-3 |
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