Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P

BACKGROUND: The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, SP/NK-1R interactions have been associated with severe neuroinflammation and neuronal damage. We ha...

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Detalles Bibliográficos
Autores principales: Burmeister, Amanda R., Johnson, M. Brittany, Chauhan, Vinita S., Moerdyk-Schauwecker, Megan J., Young, Ada D., Cooley, Ian D., Martinez, Alejandra N., Ramesh, Geeta, Philipp, Mario T., Marriott, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729418/
https://www.ncbi.nlm.nih.gov/pubmed/29237453
http://dx.doi.org/10.1186/s12974-017-1012-5

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