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Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative
BACKGROUND: Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorectal and prostate cancer within families has not been well investigated. METHODS:...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729427/ https://www.ncbi.nlm.nih.gov/pubmed/29237415 http://dx.doi.org/10.1186/s12885-017-3873-5 |
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author | Beebe-Dimmer, Jennifer L. Yee, Cecilia Paskett, Electra Schwartz, Ann G. Lane, Dorothy Palmer, Nynikka R. A. Bock, Cathryn H. Nassir, Rami Simon, Michael S. |
author_facet | Beebe-Dimmer, Jennifer L. Yee, Cecilia Paskett, Electra Schwartz, Ann G. Lane, Dorothy Palmer, Nynikka R. A. Bock, Cathryn H. Nassir, Rami Simon, Michael S. |
author_sort | Beebe-Dimmer, Jennifer L. |
collection | PubMed |
description | BACKGROUND: Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorectal and prostate cancer within families has not been well investigated. METHODS: Analyses were conducted among participants of the Women’s Health Initiative (WHI) observational cohort, free of cancer at the baseline examination. Subjects were followed for colorectal cancer through August 31st, 2009. A Cox-proportional hazards regression modeling approach was used to estimate risk of colorectal cancer associated with a family history of prostate cancer, colorectal cancer and both cancers among first-degree relatives of all participants and stratified by race (African American vs. White). RESULTS: Of 75,999 eligible participants, there were 1122 colorectal cancer cases diagnosed over the study period. A family history of prostate cancer alone was not associated with an increase in colorectal cancer risk after adjustment for confounders (aHR =0.94; 95% CI =0.76, 1.15). Separate analysis examining the joint impact, a family history of both colorectal and prostate cancer was associated with an almost 50% increase in colorectal cancer risk (aHR = 1.48; 95% CI = 1.04, 2.10), but similar to those with a family history of colorectal cancer only (95% CI = 1.31; 95% CI = 1.11, 1.54). CONCLUSIONS: Our findings suggest risk of colorectal cancer is increased similarly among women with colorectal cancer only and among those with both colorectal and prostate cancer diagnosed among first-degree family members. Future studies are needed to determine the relative contribution of genes and shared environment to the risk of both cancers. |
format | Online Article Text |
id | pubmed-5729427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57294272017-12-18 Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative Beebe-Dimmer, Jennifer L. Yee, Cecilia Paskett, Electra Schwartz, Ann G. Lane, Dorothy Palmer, Nynikka R. A. Bock, Cathryn H. Nassir, Rami Simon, Michael S. BMC Cancer Research Article BACKGROUND: Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorectal and prostate cancer within families has not been well investigated. METHODS: Analyses were conducted among participants of the Women’s Health Initiative (WHI) observational cohort, free of cancer at the baseline examination. Subjects were followed for colorectal cancer through August 31st, 2009. A Cox-proportional hazards regression modeling approach was used to estimate risk of colorectal cancer associated with a family history of prostate cancer, colorectal cancer and both cancers among first-degree relatives of all participants and stratified by race (African American vs. White). RESULTS: Of 75,999 eligible participants, there were 1122 colorectal cancer cases diagnosed over the study period. A family history of prostate cancer alone was not associated with an increase in colorectal cancer risk after adjustment for confounders (aHR =0.94; 95% CI =0.76, 1.15). Separate analysis examining the joint impact, a family history of both colorectal and prostate cancer was associated with an almost 50% increase in colorectal cancer risk (aHR = 1.48; 95% CI = 1.04, 2.10), but similar to those with a family history of colorectal cancer only (95% CI = 1.31; 95% CI = 1.11, 1.54). CONCLUSIONS: Our findings suggest risk of colorectal cancer is increased similarly among women with colorectal cancer only and among those with both colorectal and prostate cancer diagnosed among first-degree family members. Future studies are needed to determine the relative contribution of genes and shared environment to the risk of both cancers. BioMed Central 2017-12-13 /pmc/articles/PMC5729427/ /pubmed/29237415 http://dx.doi.org/10.1186/s12885-017-3873-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Beebe-Dimmer, Jennifer L. Yee, Cecilia Paskett, Electra Schwartz, Ann G. Lane, Dorothy Palmer, Nynikka R. A. Bock, Cathryn H. Nassir, Rami Simon, Michael S. Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative |
title | Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative |
title_full | Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative |
title_fullStr | Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative |
title_full_unstemmed | Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative |
title_short | Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women’s health initiative |
title_sort | family history of prostate and colorectal cancer and risk of colorectal cancer in the women’s health initiative |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729427/ https://www.ncbi.nlm.nih.gov/pubmed/29237415 http://dx.doi.org/10.1186/s12885-017-3873-5 |
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