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Towards gene- and gender-based risk estimates in Lynch syndrome; age-specific incidences for 13 extra-colorectal cancer types

BACKGROUND: In Lynch syndrome, inherited mismatch repair (MMR) defects predispose to colorectal cancer and to a wide spectrum of extra-colorectal tumours. Utilising a cohort study design, we aimed to determine the risk of extra-colorectal cancer and to identify yet unrecognised tumour types. METHODS...

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Detalles Bibliográficos
Autores principales:	Therkildsen, Christina, Ladelund, Steen, Smith-Hansen, Lars, Lindberg, Lars Joachim, Nilbert, Mef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729445/ https://www.ncbi.nlm.nih.gov/pubmed/29065108 http://dx.doi.org/10.1038/bjc.2017.348

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