Pentosan polysulfate binds to STRO-1(+) mesenchymal progenitor cells, is internalized, and modifies gene expression: a novel approach of pre-programing stem cells for therapeutic application requiring their chondrogenesis

BACKGROUND: The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS in mediating these effects remains unresolved. In the present report we address...

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Detalles Bibliográficos
Autores principales: Wu, Jiehua, Shimmon, Susan, Paton, Sharon, Daly, Christopher, Goldschlager, Tony, Gronthos, Stan, Zannettino, Andrew C. W., Ghosh, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729458/
https://www.ncbi.nlm.nih.gov/pubmed/29237492
http://dx.doi.org/10.1186/s13287-017-0723-y

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