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30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure

BACKGROUND: The current study followed-up site-specific cancer risks in an unique cohort with 30 years’ follow-up after long-term low-dose-rate radiation exposure in Taiwan. METHODS: Six thousand two hundred and forty two Taiwanese people received extra exposure in residential and school buildings c...

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Autores principales: Hsieh, Wan-Hua, Lin, I-Feng, Ho, Jung-Chun, Chang, Peter Wushou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729469/
https://www.ncbi.nlm.nih.gov/pubmed/28972968
http://dx.doi.org/10.1038/bjc.2017.350
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author Hsieh, Wan-Hua
Lin, I-Feng
Ho, Jung-Chun
Chang, Peter Wushou
author_facet Hsieh, Wan-Hua
Lin, I-Feng
Ho, Jung-Chun
Chang, Peter Wushou
author_sort Hsieh, Wan-Hua
collection PubMed
description BACKGROUND: The current study followed-up site-specific cancer risks in an unique cohort with 30 years’ follow-up after long-term low-dose-rate radiation exposure in Taiwan. METHODS: Six thousand two hundred and forty two Taiwanese people received extra exposure in residential and school buildings constructed with Co-60-contaminated steel from 1982 until informed and relocated in early 1990s. The additional doses received have been estimated. During 1983–2012, 300 cancer cases were identified through the national cancer registry in Taiwan, 247 cases with minimum latent periods from initial exposure. The hazard ratios (HR) of site-specific cancers were estimated with additional cumulative exposure estimated individually. RESULTS: Dose-dependent risks were statistically significantly increased for leukaemia excluding chronic lymphocytic leukaemia (HR(100mSv) 1.18; 90% CI 1.04–1.28), breast cancers (HR(100mSv) 1.11; 90% CI 1.05–1.20), and all cancers (HR(100mSv) 1.05; 90% CI 1.0–1.08, P=0.04). Women with an initial age of exposure lower than 20 were shown with dose response increase in breast cancers risks (HR(100mSv) 1.38; 90% CI 1.14–1.60; P=0.0008). CONCLUSIONS: Radiation exposure before age 20 was associated with a significantly increased risk of breast cancer at much lower radiation exposure than observed previously.
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spelling pubmed-57294692018-12-05 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure Hsieh, Wan-Hua Lin, I-Feng Ho, Jung-Chun Chang, Peter Wushou Br J Cancer Epidemiology BACKGROUND: The current study followed-up site-specific cancer risks in an unique cohort with 30 years’ follow-up after long-term low-dose-rate radiation exposure in Taiwan. METHODS: Six thousand two hundred and forty two Taiwanese people received extra exposure in residential and school buildings constructed with Co-60-contaminated steel from 1982 until informed and relocated in early 1990s. The additional doses received have been estimated. During 1983–2012, 300 cancer cases were identified through the national cancer registry in Taiwan, 247 cases with minimum latent periods from initial exposure. The hazard ratios (HR) of site-specific cancers were estimated with additional cumulative exposure estimated individually. RESULTS: Dose-dependent risks were statistically significantly increased for leukaemia excluding chronic lymphocytic leukaemia (HR(100mSv) 1.18; 90% CI 1.04–1.28), breast cancers (HR(100mSv) 1.11; 90% CI 1.05–1.20), and all cancers (HR(100mSv) 1.05; 90% CI 1.0–1.08, P=0.04). Women with an initial age of exposure lower than 20 were shown with dose response increase in breast cancers risks (HR(100mSv) 1.38; 90% CI 1.14–1.60; P=0.0008). CONCLUSIONS: Radiation exposure before age 20 was associated with a significantly increased risk of breast cancer at much lower radiation exposure than observed previously. Nature Publishing Group 2017-12-05 2017-10-03 /pmc/articles/PMC5729469/ /pubmed/28972968 http://dx.doi.org/10.1038/bjc.2017.350 Text en Copyright © 2017 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Hsieh, Wan-Hua
Lin, I-Feng
Ho, Jung-Chun
Chang, Peter Wushou
30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
title 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
title_full 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
title_fullStr 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
title_full_unstemmed 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
title_short 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
title_sort 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729469/
https://www.ncbi.nlm.nih.gov/pubmed/28972968
http://dx.doi.org/10.1038/bjc.2017.350
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