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Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM
Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become evident that p53-dependent repression is controlled by the p53–p21–DREAM–E2F/CHR pathway (p53–DREAM...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729532/ https://www.ncbi.nlm.nih.gov/pubmed/29125603 http://dx.doi.org/10.1038/cdd.2017.172 |