Narrowing the spectrum: the new frontier of precision antimicrobials

Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Paharik, Alexandra E., Schreiber, Henry L., Spaulding, Caitlin N., Dodson, Karen W., Hultgren, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729598/
https://www.ncbi.nlm.nih.gov/pubmed/29241446
http://dx.doi.org/10.1186/s13073-017-0504-3
_version_ 1783286222694645760
author Paharik, Alexandra E.
Schreiber, Henry L.
Spaulding, Caitlin N.
Dodson, Karen W.
Hultgren, Scott J.
author_facet Paharik, Alexandra E.
Schreiber, Henry L.
Spaulding, Caitlin N.
Dodson, Karen W.
Hultgren, Scott J.
author_sort Paharik, Alexandra E.
collection PubMed
description Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.
format Online
Article
Text
id pubmed-5729598
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-57295982017-12-18 Narrowing the spectrum: the new frontier of precision antimicrobials Paharik, Alexandra E. Schreiber, Henry L. Spaulding, Caitlin N. Dodson, Karen W. Hultgren, Scott J. Genome Med Comment Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens. BioMed Central 2017-12-14 /pmc/articles/PMC5729598/ /pubmed/29241446 http://dx.doi.org/10.1186/s13073-017-0504-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Paharik, Alexandra E.
Schreiber, Henry L.
Spaulding, Caitlin N.
Dodson, Karen W.
Hultgren, Scott J.
Narrowing the spectrum: the new frontier of precision antimicrobials
title Narrowing the spectrum: the new frontier of precision antimicrobials
title_full Narrowing the spectrum: the new frontier of precision antimicrobials
title_fullStr Narrowing the spectrum: the new frontier of precision antimicrobials
title_full_unstemmed Narrowing the spectrum: the new frontier of precision antimicrobials
title_short Narrowing the spectrum: the new frontier of precision antimicrobials
title_sort narrowing the spectrum: the new frontier of precision antimicrobials
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729598/
https://www.ncbi.nlm.nih.gov/pubmed/29241446
http://dx.doi.org/10.1186/s13073-017-0504-3
work_keys_str_mv AT paharikalexandrae narrowingthespectrumthenewfrontierofprecisionantimicrobials
AT schreiberhenryl narrowingthespectrumthenewfrontierofprecisionantimicrobials
AT spauldingcaitlinn narrowingthespectrumthenewfrontierofprecisionantimicrobials
AT dodsonkarenw narrowingthespectrumthenewfrontierofprecisionantimicrobials
AT hultgrenscottj narrowingthespectrumthenewfrontierofprecisionantimicrobials

Ejemplares similares