m(6)A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

N6 -methyladenosine (m(6)A) is the most common and abundant messenger RNA modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark (1,2). In vitro data have shown that m(6)A influences all fundamental aspects of mRNA metabolism, mainly mRNA stability, to determine stem cell fates (...

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Detalles Bibliográficos
Autores principales: Li, Hua-Bing, Tong, Jiyu, Zhu, Shu, Batista, Pedro J., Duffy, Erin E., Zhao, Jun, Bailis, Will, Cao, Guangchao, Kroehling, Lina, Chen, Yuanyuan, Wang, Geng, Broughton, James P., Chen, Y. Grace, Kluger, Yuval, Simon, Matthew D., Chang, Howard Y., Yin, Zhinan, Flavell, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729908/
https://www.ncbi.nlm.nih.gov/pubmed/28792938
http://dx.doi.org/10.1038/nature23450

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