Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Energetic nutrients are oxidized to sustain high intra-cellular NADPH/NADP(+) ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleot...

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Detalles Bibliográficos
Autores principales: Prigge, Justin R., Coppo, Lucia, Martin, Sebastin S., Ogata, Fernando, Miller, Colin G., Bruschwein, Michael D., Orlicky, David J., Shearn, Colin T., Kundert, Jean A., Lytchier, Julia, Herr, Alix E., Mattsson, Åse, Taylor, Matthew P., Gustafsson, Tomas N., Arnér, Elias S.J., Holmgren, Arne, Schmidt, Edward E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730093/
https://www.ncbi.nlm.nih.gov/pubmed/28658624
http://dx.doi.org/10.1016/j.celrep.2017.06.019

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