Cargando…

Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers

Although a large amount of acoustic indicators have already been proposed in the literature to evaluate the hypokinetic dysarthria of people with Parkinson’s Disease, the goal of this work is to identify and interpret new reliable and complementary articulatory biomarkers that could be applied to pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Godino-Llorente, J. I., Shattuck-Hufnagel, S., Choi, J. Y., Moro-Velázquez, L., Gómez-García, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730127/
https://www.ncbi.nlm.nih.gov/pubmed/29240814
http://dx.doi.org/10.1371/journal.pone.0189583
_version_ 1783286300572385280
author Godino-Llorente, J. I.
Shattuck-Hufnagel, S.
Choi, J. Y.
Moro-Velázquez, L.
Gómez-García, J. A.
author_facet Godino-Llorente, J. I.
Shattuck-Hufnagel, S.
Choi, J. Y.
Moro-Velázquez, L.
Gómez-García, J. A.
author_sort Godino-Llorente, J. I.
collection PubMed
description Although a large amount of acoustic indicators have already been proposed in the literature to evaluate the hypokinetic dysarthria of people with Parkinson’s Disease, the goal of this work is to identify and interpret new reliable and complementary articulatory biomarkers that could be applied to predict/evaluate Parkinson’s Disease from a diadochokinetic test, contributing to the possibility of a further multidimensional analysis of the speech of parkinsonian patients. The new biomarkers proposed are based on the kinetic behaviour of the envelope trace, which is directly linked with the articulatory dysfunctions introduced by the disease since the early stages. The interest of these new articulatory indicators stands on their easiness of identification and interpretation, and their potential to be translated into computer based automatic methods to screen the disease from the speech. Throughout this paper, the accuracy provided by these acoustic kinetic biomarkers is compared with the one obtained with a baseline system based on speaker identification techniques. Results show accuracies around 85% that are in line with those obtained with the complex state of the art speaker recognition techniques, but with an easier physical interpretation, which open the possibility to be transferred to a clinical setting.
format Online
Article
Text
id pubmed-5730127
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-57301272017-12-22 Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers Godino-Llorente, J. I. Shattuck-Hufnagel, S. Choi, J. Y. Moro-Velázquez, L. Gómez-García, J. A. PLoS One Research Article Although a large amount of acoustic indicators have already been proposed in the literature to evaluate the hypokinetic dysarthria of people with Parkinson’s Disease, the goal of this work is to identify and interpret new reliable and complementary articulatory biomarkers that could be applied to predict/evaluate Parkinson’s Disease from a diadochokinetic test, contributing to the possibility of a further multidimensional analysis of the speech of parkinsonian patients. The new biomarkers proposed are based on the kinetic behaviour of the envelope trace, which is directly linked with the articulatory dysfunctions introduced by the disease since the early stages. The interest of these new articulatory indicators stands on their easiness of identification and interpretation, and their potential to be translated into computer based automatic methods to screen the disease from the speech. Throughout this paper, the accuracy provided by these acoustic kinetic biomarkers is compared with the one obtained with a baseline system based on speaker identification techniques. Results show accuracies around 85% that are in line with those obtained with the complex state of the art speaker recognition techniques, but with an easier physical interpretation, which open the possibility to be transferred to a clinical setting. Public Library of Science 2017-12-14 /pmc/articles/PMC5730127/ /pubmed/29240814 http://dx.doi.org/10.1371/journal.pone.0189583 Text en © 2017 Godino-Llorente et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Godino-Llorente, J. I.
Shattuck-Hufnagel, S.
Choi, J. Y.
Moro-Velázquez, L.
Gómez-García, J. A.
Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers
title Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers
title_full Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers
title_fullStr Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers
title_full_unstemmed Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers
title_short Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers
title_sort towards the identification of idiopathic parkinson’s disease from the speech. new articulatory kinetic biomarkers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730127/
https://www.ncbi.nlm.nih.gov/pubmed/29240814
http://dx.doi.org/10.1371/journal.pone.0189583
work_keys_str_mv AT godinollorenteji towardstheidentificationofidiopathicparkinsonsdiseasefromthespeechnewarticulatorykineticbiomarkers
AT shattuckhufnagels towardstheidentificationofidiopathicparkinsonsdiseasefromthespeechnewarticulatorykineticbiomarkers
AT choijy towardstheidentificationofidiopathicparkinsonsdiseasefromthespeechnewarticulatorykineticbiomarkers
AT morovelazquezl towardstheidentificationofidiopathicparkinsonsdiseasefromthespeechnewarticulatorykineticbiomarkers
AT gomezgarciaja towardstheidentificationofidiopathicparkinsonsdiseasefromthespeechnewarticulatorykineticbiomarkers