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Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore

BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman’s ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between...

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Autores principales: Loy, See Ling, Cheung, Yin Bun, Fortier, Marielle Valerie, Ong, Chiou Li, Tan, Heng Hao, Nadarajah, Sadhana, Chan, Jerry Kok Yen, Viardot-Foucault, Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730199/
https://www.ncbi.nlm.nih.gov/pubmed/29240820
http://dx.doi.org/10.1371/journal.pone.0189830
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author Loy, See Ling
Cheung, Yin Bun
Fortier, Marielle Valerie
Ong, Chiou Li
Tan, Heng Hao
Nadarajah, Sadhana
Chan, Jerry Kok Yen
Viardot-Foucault, Veronique
author_facet Loy, See Ling
Cheung, Yin Bun
Fortier, Marielle Valerie
Ong, Chiou Li
Tan, Heng Hao
Nadarajah, Sadhana
Chan, Jerry Kok Yen
Viardot-Foucault, Veronique
author_sort Loy, See Ling
collection PubMed
description BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman’s ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women’s and Children’s Hospital, Singapore. Ordinary least squares regression analysis was used to estimate the relationship of AFC and AMH with age, while age-related AFC and AMH nomograms for the 3(rd), 10(th), 25(th), 50(th), 75(th), 90(th) and 97(th) percentiles were produced using the lambda-mu-sigma method. RESULTS: A total of 1,009 women, aged 26 to 44 year-old, were included. On average, the AFC and AMH decreased respectively by 0.79 follicle (95% confidence interval -0.93, -0.64) and 0.38 ng/mL (95% confidence interval -0.43, -0.32) per year of age. The age-related nomograms of AFC showed an approximately linear pattern, inversely correlated with age, regardless of the percentile. For AMH, the pattern is linear for the 75(th) percentile and below but shows a slightly accelerating decline for the 90(th) and 97(th) percentile. Overall, there were large inter-individual variations in AFC and AMH up to about 40 year-old. CONCLUSION: The declines of AFC and AMH over age are mostly linear among subfertile Chinese women in Singapore. The age-related AFC and AMH nomograms could be used as a reference chart by fertility practitioners. However, future validation with longitudinal data is required.
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spelling pubmed-57301992017-12-22 Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore Loy, See Ling Cheung, Yin Bun Fortier, Marielle Valerie Ong, Chiou Li Tan, Heng Hao Nadarajah, Sadhana Chan, Jerry Kok Yen Viardot-Foucault, Veronique PLoS One Research Article BACKGROUND: Antral follicle count (AFC) and anti-Mullerian hormone (AMH) are known as the most reliable markers of a woman’s ovarian reserve and are related to age. There is currently no specific local age-related centile charts for AFC and AMH. Therefore, we aim to examine the relationship between AFC and AMH with age and construct age-related nomograms among a subfertile Asian population. METHODS: This is a study involving Chinese women who had their AFC and AMH measured as part of their subfertility screening from December 2010 until November 2014 in KK Women’s and Children’s Hospital, Singapore. Ordinary least squares regression analysis was used to estimate the relationship of AFC and AMH with age, while age-related AFC and AMH nomograms for the 3(rd), 10(th), 25(th), 50(th), 75(th), 90(th) and 97(th) percentiles were produced using the lambda-mu-sigma method. RESULTS: A total of 1,009 women, aged 26 to 44 year-old, were included. On average, the AFC and AMH decreased respectively by 0.79 follicle (95% confidence interval -0.93, -0.64) and 0.38 ng/mL (95% confidence interval -0.43, -0.32) per year of age. The age-related nomograms of AFC showed an approximately linear pattern, inversely correlated with age, regardless of the percentile. For AMH, the pattern is linear for the 75(th) percentile and below but shows a slightly accelerating decline for the 90(th) and 97(th) percentile. Overall, there were large inter-individual variations in AFC and AMH up to about 40 year-old. CONCLUSION: The declines of AFC and AMH over age are mostly linear among subfertile Chinese women in Singapore. The age-related AFC and AMH nomograms could be used as a reference chart by fertility practitioners. However, future validation with longitudinal data is required. Public Library of Science 2017-12-14 /pmc/articles/PMC5730199/ /pubmed/29240820 http://dx.doi.org/10.1371/journal.pone.0189830 Text en © 2017 Loy et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Loy, See Ling
Cheung, Yin Bun
Fortier, Marielle Valerie
Ong, Chiou Li
Tan, Heng Hao
Nadarajah, Sadhana
Chan, Jerry Kok Yen
Viardot-Foucault, Veronique
Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore
title Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore
title_full Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore
title_fullStr Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore
title_full_unstemmed Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore
title_short Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore
title_sort age-related nomograms for antral follicle count and anti-mullerian hormone for subfertile chinese women in singapore
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730199/
https://www.ncbi.nlm.nih.gov/pubmed/29240820
http://dx.doi.org/10.1371/journal.pone.0189830
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