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An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway
To optimize fitness a plant should monitor its metabolism to appropriately control growth and defense. Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the available energy and nutrients. Recent work suggests tha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730369/ https://www.ncbi.nlm.nih.gov/pubmed/29231169 http://dx.doi.org/10.7554/eLife.29353 |
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author | Malinovsky, Frederikke Gro Thomsen, Marie-Louise F Nintemann, Sebastian J Jagd, Lea Møller Bourgine, Baptiste Burow, Meike Kliebenstein, Daniel J |
author_facet | Malinovsky, Frederikke Gro Thomsen, Marie-Louise F Nintemann, Sebastian J Jagd, Lea Møller Bourgine, Baptiste Burow, Meike Kliebenstein, Daniel J |
author_sort | Malinovsky, Frederikke Gro |
collection | PubMed |
description | To optimize fitness a plant should monitor its metabolism to appropriately control growth and defense. Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the available energy and nutrients. Recent work suggests that plants may measure defense metabolites to potentially provide a strategy ensuring fast reallocation of resources to coordinate plant growth and defense. There is little understanding of mechanisms enabling defense metabolite signaling. To identify mechanisms of defense metabolite signaling, we used glucosinolates, an important class of plant defense metabolites. We report novel signaling properties specific to one distinct glucosinolate, 3-hydroxypropylglucosinolate across plants and fungi. This defense metabolite, or derived compounds, reversibly inhibits root growth and development. 3-hydroxypropylglucosinolate signaling functions via genes in the ancient TOR pathway. If this event is not unique, this raises the possibility that other evolutionarily new plant metabolites may link to ancient signaling pathways. |
format | Online Article Text |
id | pubmed-5730369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57303692017-12-15 An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway Malinovsky, Frederikke Gro Thomsen, Marie-Louise F Nintemann, Sebastian J Jagd, Lea Møller Bourgine, Baptiste Burow, Meike Kliebenstein, Daniel J eLife Plant Biology To optimize fitness a plant should monitor its metabolism to appropriately control growth and defense. Primary metabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the available energy and nutrients. Recent work suggests that plants may measure defense metabolites to potentially provide a strategy ensuring fast reallocation of resources to coordinate plant growth and defense. There is little understanding of mechanisms enabling defense metabolite signaling. To identify mechanisms of defense metabolite signaling, we used glucosinolates, an important class of plant defense metabolites. We report novel signaling properties specific to one distinct glucosinolate, 3-hydroxypropylglucosinolate across plants and fungi. This defense metabolite, or derived compounds, reversibly inhibits root growth and development. 3-hydroxypropylglucosinolate signaling functions via genes in the ancient TOR pathway. If this event is not unique, this raises the possibility that other evolutionarily new plant metabolites may link to ancient signaling pathways. eLife Sciences Publications, Ltd 2017-12-12 /pmc/articles/PMC5730369/ /pubmed/29231169 http://dx.doi.org/10.7554/eLife.29353 Text en © 2017, Malinovsky et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Plant Biology Malinovsky, Frederikke Gro Thomsen, Marie-Louise F Nintemann, Sebastian J Jagd, Lea Møller Bourgine, Baptiste Burow, Meike Kliebenstein, Daniel J An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway |
title | An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway |
title_full | An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway |
title_fullStr | An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway |
title_full_unstemmed | An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway |
title_short | An evolutionarily young defense metabolite influences the root growth of plants via the ancient TOR signaling pathway |
title_sort | evolutionarily young defense metabolite influences the root growth of plants via the ancient tor signaling pathway |
topic | Plant Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730369/ https://www.ncbi.nlm.nih.gov/pubmed/29231169 http://dx.doi.org/10.7554/eLife.29353 |
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