The GDNF Family: A Role in Cancer?

The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis. Here we review our...

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Detalles Bibliográficos
Autores principales: Fielder, Graeme C., Yang, Teresa Wen-Shan, Razdan, Mahalakshmi, Li, Yan, Lu, Jun, Perry, Jo K., Lobie, Peter E., Liu, Dong-Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Review article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730419/
https://www.ncbi.nlm.nih.gov/pubmed/29245123
http://dx.doi.org/10.1016/j.neo.2017.10.010
Descripción
Sumario:The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis. Here we review our current understanding of GFL biology, and supported by recent progress in the area, we examine their emerging role in endocrine-related and other non–hormone-dependent solid neoplasms. The ability of GFLs to elicit actions that resemble those perturbed in an oncogenic phenotype, alongside mounting evidence of GFL involvement in tumor progression, presents novel opportunities for therapeutic intervention.

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