A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions

Assessment of pharmacodynamic (PD) drug interactions is a cornerstone of the development of combination drug therapies. To guide this venture, we derive a general pharmacodynamic interaction (GPDI) model for ≥2 interacting drugs that is compatible with common additivity criteria. We propose a PD int...

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Detalles Bibliográficos
Autores principales: Wicha, Sebastian G., Chen, Chunli, Clewe, Oskar, Simonsson, Ulrika S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730559/
https://www.ncbi.nlm.nih.gov/pubmed/29242552
http://dx.doi.org/10.1038/s41467-017-01929-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730559/
https://www.ncbi.nlm.nih.gov/pubmed/29242552
http://dx.doi.org/10.1038/s41467-017-01929-y

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